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課程名稱 |
健康與疾病發展起源(上)
DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (I) |
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開課學期 |
97-1 |
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授課對象 |
公共衛生學院 職業醫學與工業衛生研究所 |
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授課教師 |
陳保中 |
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課號 |
OMIH5057 |
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課程識別碼 |
841 U5400 |
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班次 |
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學分 |
2 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期三5,6(12:20~14:10) |
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上課地點 |
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備註 |
上課地點：基礎醫學大樓507教室。與謝武勳合開
總人數上限：30人
外系人數限制：30人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/971dohad |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
健康與疾病發展起源主要以出生世代進行長期追蹤研究，進行跨領域科學合作，以瞭解健康與疾病的發展起源，現階段將以主要兒童健康與疾病議題進行探討，包括早產及其預後、兒童成長與肥胖、過敏性疾病、神經行為與語言發展、子宮內與早期嬰幼兒環境暴露、基因與環境交互作用；未來將擴展致成人疾病早期指標的探討，包括心血管疾病、糖尿病、慢性呼吸道疾病等；最終將研擬合適的疾病預防的早期介入方法及策略，以有效降低兒童及成人慢性疾病。 |
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課程目標 |
健康與疾病發展起源主要以出生世代進行長期追蹤研究，進行跨領域科學合作，以瞭解健康與疾病的發展起源，現階段將以主要兒童健康與疾病議題進行探討，包括早產及其預後、兒童成長與肥胖、過敏性疾病、神經行為與語言發展、子宮內與早期嬰幼兒環境暴露、基因與環境交互作用；未來將擴展致成人疾病早期指標的探討，包括心血管疾病、糖尿病、慢性呼吸道疾病等；最終將研擬合適的疾病預防的早期介入方法及策略，以有效降低兒童及成人慢性疾病。 |
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課程要求 |
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預期每週課後學習時數 |
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Office Hours |
每週三 15:30~17:20 |
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指定閱讀 |
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參考書目 |
1. Barker DJP, ed. Fetal and Infant Origins of Adult
Disease. London: BMJ Publishing Group, 1992
2. Barker DJP. Mothers, Babies, and Disease in Later Life.
London: BMJ Publishing Group, 1994.
3. Kuh D, Hardy Rebecca, eds. A Life Course Approach to
Women’s Health. Oxford: Oxford University Press, 2002.
4. Kuh D, Ben-Shlomo Y, eds. A Life Course Approach to
Chronic Disease Epidemiology, Second Edition. Oxford:
Oxford University Press, 2004.
5. Lauer RM, Burns TL, Daniels SR, eds. Pediatric
Prevention of Atherosclerotic Cardiovascular Disease. New
York: Oxford University Press, 2006.
6. Gluckman P, Hanson M, eds. Developmental Origins of
Health and Disease. Cambridge: Cambridge University Press,
2006.
7. Wintour EM, Owens JA, eds. Early life origins of health
and disease (Advances in Experimental Medicine and
Biology). New York: Springer Science+Business Media,
Georgetown, 2006. |
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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第1週 |
09/17 |
Introduction |
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第2週 |
09/24 |
Workshop for the Taiwan Birth Panel Study |
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第3週 |
10/01 |
Workshop for the Taiwan Birth Panel Study |
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第4週 |
10/08 |
全氟碳化合物暴露評估、健康效應及風險評估 |
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第5週 |
10/15 |
Introduction of web-based microarray analytic platform |
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第6週 |
10/22 |
DNA analysis |
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第7週 |
10/29 |
microaRNA and next generation sequencing |
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第8週 |
11/05 |
1. Introduction to endocrine-disrupting chemicals
2. Endocrine disruption and the female |
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第9週 |
11/12 |
3. Endocrine disruption in the male |
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第10週 |
11/19 |
4. Endocrine disruption and the brain |
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第11週 |
11/26 |
5. Heavy metals as endocrine-disrupting chemicals |
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第12週 |
12/03 |
6. Cellular mechanisms of endocrine disruption: traditional and novel actions |
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第13週 |
12/10 |
7. Endocrine disruptors, epigenetically induced changes, and transgenerational transmission of characters and epigenetic states
8. Implications of thyroid hormone signaling through the
phosphoinositide-3 kinase for xenobiotic disruption of human health |
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第14週 |
12/17 |
9. Endocrine disruption and reproductive outcomes in women |
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第15週 |
12/24 |
10. Epidemiologic evidence on the relationship between environmental endocrine disruptors and male reproductive and developmental health |
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第16週 |
12/31 |
11. Human exposures and body burdens of endocrine-disrupting chemicals 12. Policy implications of endocrine-disrupting chemicals in humans |
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第17週 |
2009/01/07 |
13. Talking with patients and the public about endocrine-disrupting chemicals14. Community interventions to reduce exposures to chemicals with endocrine disrupting properties
15. What can we do about endocrine-disrupting chemicals?
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第18週 |
2009/01/14 |
期末考 |
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